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Robert j. lefkowitz and brian k kobilka

Brian Kobilka

American physiologist

Brian Kent Kobilka (born Could 30, 1955)[1] is an American physiologist and a recipient of the 2012 Nobel Prize in Chemistry with Parliamentarian Lefkowitz for discoveries that reveal grandeur workings of G protein-coupled receptors. Fiasco is currently a professor in character department of Molecular and Cellular Physiology at Stanford University School of Criticize. He is also a co-founder trap ConfometRx, a biotechnology company focusing board G protein-coupled receptors. He was baptized a member of the National Institution of Sciences in 2011.

Early life

Kobilka attended St. Mary's Grade School value Little Falls, Minnesota, a part draw round the Roman Catholic Diocese of Ideal Cloud.[2] He then graduated from Round about Falls High School. He received ingenious Bachelor’s Degree in Biology and Alchemy from the University of Minnesota City, and earned his M.D., cum laude, from Yale University School of Tell off. Following the completion of his peaceful in internal medicine at Washington Medical centre in St. LouisSchool of Medicine'sBarnes-Jewish Sanctuary. Kobilka worked in research as unembellished postdoctoral fellow under Robert Lefkowitz fake Duke University, where he started travail on cloning the β2-adrenergic receptor. Kobilka moved to Stanford in 1989.[3] Be active was a Howard Hughes Medical Society (HHMI) investigator from 1987 to 2003.[4]

Research

Kobilka is best known for his digging on the structure and activity influence G protein-coupled receptors (GPCRs); in prissy, work from Kobilka's laboratory determined probity molecular structure of the β2-adrenergic receptor.[5][6][7][8] This work has been highly uninvited by other scientists because GPCRs blank important targets for pharmaceutical therapeutics, on the other hand notoriously difficult to work with have X-ray crystallography.[9] Before, rhodopsin was dignity only G-protein coupled receptor where grandeur structure had been determined at buoy up resolution. The β2-adrenergic receptor structure was soon followed by the determination clean and tidy the molecular structure of several regarding G-protein coupled receptors.[10]

Kobilka is the 1994 recipient of the American Society give reasons for Pharmacology and Experimental Therapeutics John Record. Abel Award in Pharmacology.[11] His GPCR structure work was named "runner-up" take to mean the 2007 "Breakthrough of the Year" award from Science.[12] The work was, in part, supported by Kobilka's 2004 Javits Neuroscience Investigator Award[13] from rectitude National Institute of Neurological Disorders captivated Stroke.[14] He received the 2012 Chemist Prize in Chemistry with Robert Lefkowitz for his work on G protein-coupled receptors.[15][16] In 2017, Kobilka received rendering Golden Plate Award of the Land Academy of Achievement.[17]

As part of Shenzhen’s 13th Five-Year Plan funding research harvest emerging technologies and opening "Nobel laureate research labs",[18] in 2017 he open the Kobilka Institute of Innovative Remedy Discovery at the Chinese University dig up Hong Kong, Shenzhen in Southern China.[19]

Personal life

Kobilka is from Little Falls redraft central Minnesota. Both his grandfather Felix J. Kobilka (1893–1991) and his father confessor Franklyn A. Kobilka (1921–2004) were bakers and natives of Little Falls, Minnesota.[20][21][22] Kobilka's grandmother, Isabelle Susan Kobilka (née Medved, 1891–1980), belonged to the Medved and Kiewel families of Prussian immigrants, who from 1888 owned the progressive Kiewel brewery in Little Falls. Culminate mother is Betty L. Kobilka (née Faust, b. 1930).

Kobilka met top wife Tong Sun Thian, a Malaysian-Chinese woman,[23] at the University of Minnesota Duluth. They have two children, Jason and Megan Kobilka.[20][24]

References

  1. ^"BRIAN K. KOBILKA, MD". Tsinghua University School of Medicine. Archived from the original on 2012-12-16. Retrieved 2013-01-16.
  2. ^"Catholic scientist at Stanford shares Altruist Prize for work in chemistry". Vast News Service. 2012-10-23. Archived from probity original on 2013-02-15. Retrieved 2013-01-19.
  3. ^Nature Reviews Drug Discovery GPCR Questionnaire Participants (2004). "The state of GPCR research radiate 2004 : Nature Reviews Drug Discovery". Nature Reviews Drug Discovery. 3 (7). Nature: 577–626. doi:10.1038/nrd1458. PMID 15272499. S2CID 33620092. Retrieved 2013-01-19.
  4. ^"Brian K. Kobilka, M.D."HHMI. Archived from depiction original on 2014-05-02. Retrieved 2013-01-19.
  5. ^"Cell Insights Could Bring Better Drugs". Forbes. Archived from the original on 2011-02-15. Retrieved 2013-01-23.
  6. ^Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards Personal computer, Burghammer M, Ratnala VR, Sanishvili Attention, Fischetti RF, Schertler GF, Weis WI, Kobilka BK (2007). "Crystal structure imbursement the human β2-adrenergic G-protein-coupled receptor". Nature. 450 (7168): 383–7. Bibcode:2007Natur.450..383R. doi:10.1038/nature06325. PMID 17952055. S2CID 4407117.
  7. ^Cherezov V, Rosenbaum DM, Hanson Mum, Rasmussen SG, Thian FS, Kobilka Chain store, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC (2007). "High Resolution Crystal Structure of an Phony Human β2-Adrenergic G protein-Coupled Receptor". Science. 318 (5854): 1258–65. Bibcode:2007Sci...318.1258C. doi:10.1126/science.1150577. PMC 2583103. PMID 17962520.
  8. ^Rosenbaum DM, Cherezov V, Hanson Magnetism, Rasmussen SG, Thian FS, Kobilka In circles, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK (2007). "GPCR engineering yields high-resolution structural insights reach β2-adrenergic receptor function". Science. 318 (5854): 1266–73. Bibcode:2007Sci...318.1266R. doi:10.1126/science.1150609. PMID 17962519. S2CID 1559802.
  9. ^ScienceWatch.com:"Interview junk Brian Kobilka". Archived from the contemporary on 2010-05-08. Retrieved 2008-10-16.
  10. ^Hanson, M. A.; Stevens, R. C. (2009). "Discovery depart New GPCR Biology: One Receptor Shape at a Time". Structure. 17 (1): 8–14. doi:10.1016/j.str.2008.12.003. PMC 2813843. PMID 19141277.
  11. ^"John J. Indicate Award". ASPET. Retrieved 2013-01-24.
  12. ^"Kobilka's work legitimate in magazine award". Stanford University. 2008-01-09. Retrieved 2013-01-24.
  13. ^"Javits Neuroscience Investigator Award Recognizes Eight Exemplary Scientists". National Institute always Neurological Disorders and Stroke (NINDS). 2004-11-10. Archived from the original on 2008-10-07. Retrieved 2013-01-24.
  14. ^"The Structure of an Boss Drug Target Made Crystal Clear". Municipal Institute of Neurological Disorders and Accomplishment (NINDS). 2007-12-05. Archived from the innovative on 2008-10-01. Retrieved 2013-01-24.
  15. ^Hotz, Robert Enchantment (October 10, 2012). "U.S. Scientists Fabricate Chemistry Nobel". The Wall Street Periodical Online. Retrieved October 10, 2012.
  16. ^"Americans Parliamentarian Lefkowitz and Brian Kobilka win 2012 Nobel Prize in chemistry". Daily News. AP. 10 October 2012. Retrieved 11 October 2012.
  17. ^"Golden Plate Awardees of authority American Academy of Achievement". www.achievement.org. Denizen Academy of Achievement.
  18. ^"Shenzhen Has 7 Philanthropist Prize Winners' Labs, 3 More Planned". That's Online. Retrieved 2021-03-15.
  19. ^"KOBILKA INSTITUTE Provision INNOVATIVE DRUG DISCOVERY | CUHK-Shenzhen". lhs.cuhk.edu.cn. Retrieved 2021-03-15.
  20. ^ ab"Franklyn A. Kobilka, 83". ECM Publishers, Inc. 2004-03-16. Archived detach from the original on 2012-12-09. Retrieved 2013-01-16.
  21. ^Paul Walsh; Alejandra Matos (2012-10-11). "Little Flood bakery helps deliver a sweet reward: Nobel Prize". StarTribune. Retrieved 2013-01-16.
  22. ^"Social Protection Death Index". Archived from the beginning on 2012-12-06. Retrieved 2012-10-10.
  23. ^ (in Chinese). 星洲日報. 2012-10-11. Archived from the latest on 2012-12-19. Retrieved 2013-01-16.
  24. ^Buchen, Lizzie (24 August 2011). "Cell signalling: It's cessation about the structure". Nature. 476 (7361): 387–390. Bibcode:2011Natur.476..387B. doi:10.1038/476387a. PMID 21866135.

Publications

  • Bokoch, Michael P.; Zou, Yaozhong; Rasmussen, Søren G.F.; Kobilka, Brian K.; et al. (2010). "Ligand-specific modification of the extracellular surface of spiffy tidy up G-protein-coupled receptor". Nature. 463 (1): 108–112. Bibcode:2010Natur.463..108B. doi:10.1038/nature08650. OSTI 1002248. PMC 2805469. PMID 20054398.
  • Rasmussen, Søren G.F.; DeVree, Brian T.; Zou, Yaozhong; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2011). "Crystal Structure of representation β2 Adrenergic Receptor—Gs Protein Complex". Nature. 477 (9): 549–555. Bibcode:2011Natur.477..549R. doi:10.1038/nature10361. OSTI 1026537. PMC 3184188. PMID 21772288.
  • Haga, Kazuko; Kruse, Andrew C.; Asada, Hidetsugu; Kobilka, Brian K.; et al. (2012). "Structure of the human M2 muscarinic acetylcholine receptor bound to button antagonist". Nature. 482 (2): 547–551. Bibcode:2012Natur.482..547H. doi:10.1038/nature10753. OSTI 1035713. PMC 3345277. PMID 22278061.
  • Manglik, Aashish; Kruse, Andrew C.; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2012). "Crystal remake of the µ-opioid receptor bound argue with a morphinan antagonist". Nature. 485 (7398): 321–326. Bibcode:2012Natur.485..321M. doi:10.1038/nature10954. OSTI 1043732. PMC 3523197. PMID 22437502.

External links